The K-M plotter (Figure 1) showed that patients with PLCE1 high-expression had lower OS and PFS in both two data sets [data set 205112, OS, HR (95% CI) = 1.34 (1.1–1.63), P < 0.01, PFS, HR (95% CI) = 1.4 (1.07–1.84), P = 0.01; data set 214159, OS, HR (95% CI) = 2.03 (1.71–2.40), P < 0.001, PFS, HR (95% CI) = 2.52 (2.01–3.16), P < 0.001], which indicated that PLCE1 increased the risk of a poor prognosis in GC patients. This evidence concerns the gene PLCE1 and gastric cancer.