KEGG enrichment analysis revealed that PLCE1 had a high correlation with inositol phosphate metabolism, phosphatidylinositol signaling system, choline metabolism in cancer, Fc gamma R-mediated phagocytosis, regulation of actin cytoskeleton, endocytosis, calcium signaling pathway, proteoglycans in cancer, rap1 signaling pathway and Ras signaling and metabolic pathways (Figure 4). This evidence concerns the gene PLCE1 and cancer.