PLCE1 and gastric cancer: This study aimed to analyze the relationship between three SNPs (rs3765524, rs2274223, and rs378126) in the PLCE1 gene and GC susceptibility by a case-control study in the Chinese Han population firstly; then we explored the prognostic value of PLCE1 in GC using online databases; finally, we tried to explain the correlation mechanism between the SNPs in PLCE1 and the risk and prognosis of GC from the perspective of variable bioinformatics and protein spatial structure changes.