ABCG2 and hyperuricemia: Similarly, Shih-Tsung Cheng and his colleagues determined that the ABCG2 rs2231142 risk allele exerted a greater effect on frequency of hyperuricemia, especially in obese patients in an East Asian cohort, but the difference in serum uric acid level was not significant in nonobese patients with this risk allele (Cheng et al., 2017).