Combination therapies with agents that target other pathways such as CD28:CD80/86 constimulation with abatacept (89), Rho-associated kinase 2 with belumosudil (90), or CSF-1R blockade with axatilimab (91) may also prove beneficial as we refine our understanding of the pathogenic pathways controlling development of GVHD. This evidence concerns the gene CSF1R and graft versus host disease.