PEG10 and chronic rhinosinusitis with nasal polyps: Assessment of overall plasma concentrations for this SPM family (i.e., the sum of MaR1, 7S,14S-diHDHA, MaR2, 22-OH-MaR1, 22-COOH-MaR1, 14-oxo-MaR1, 4,14-diHDHA, MaR1n-3 DPA, MaR2n-3 DPA and 7S,14S-diHDPA) demonstrated a significant decreased in plasma concentrations of these mediators in the CRSwNP cohort when compared to healthy controls (Figure 2A).