Copy number variations (either deletion or amplification) of PARP1 were significantly linked with lower six types of immune infiltrates in many tumors like head and neck squamous cell carcinoma, kidney renal clear cell carcinoma, lung adenocarcinoma, pancreatic adenocarcinoma, skin cutaneous melanoma and endometrial cancer (Supplementary Figures S5C-H). The gene discussed is PARP1; the disease is head and neck squamous cell carcinoma.