In addition, high PARP1 expression was positively associated with microsatellite instability event in COAD, KIRP, BRCA, GBM, LUSC, LGG, READ, UCEC, SKCM and LUAD, indicating that these tumors with high PARP1 expression could have a better response rate to ICIs immunotherapy, in particular, for LUAD, COAD and READ, LGG with high PARP1 expression, which still needs to be verified in future studies. Here, PARP1 is linked to colon adenocarcinoma.