We found that most tumors had high expression of PARP1 mRNA, compared to corresponding normal tissues, and there was a worse prognosis in patients with high expression for several tumors, suggesting that PAPR1 plays an oncogenic role to some extent in multiple tumors, which is consistent with the findings of previous studies on different tumors, such as colorectal cancer (35), gastric cancer (36) and sarcoma (37). The gene discussed is PARP1; the disease is colorectal cancer.