PARP1 and pancreatic adenocarcinoma: Finally, we found that PARP1 expression was closely linked to microsatellite instability event, which suggested that high PARP1 expression was positively associated with microsatellite instability event in COAD, KIRP, BRCA, glioblastoma multiforme (GBM), lung squamous cell carcinoma (LUSC), LGG, READ, UCEC, SKCM and LUAD, while a negative association was observed in PAAD (Figure 10B).