We found the co-occurrence of genetic mutations in tumors with PARP1 alterations to be involved with some genes such as KMT2D/2C as driver genes, PIK3CA, ARID1A, H3F3A, HIST3H3, RYR2, and thus, PARP1 alteration should promote tumor mutability. The gene discussed is H3-4; the disease is neoplasm.