These 12 variants could be divided into four subgroups according to the biological function of the affected gene, including i) autophagy (LGALS8, TECPR1), ii) Kawasaki disease (PEAR1, ERAP1), iii) viral restriction factors (PLIN3, EXOSC5, RNASE2), and iv) immune responses (ERAP1, SIGLEC15, GAB2, GOLGA4, SNX3). Here, SIGLEC15 is linked to Kawasaki disease.