CD4 and neoplasm: Specifically, MSI-high tumors were characterized by significantly higher densities of CD8+ T lymphocytes, CD20+ B cells, and tumor-infiltrating CD4+ T cells as well as higher CD66b+ neutrophil and CD68+ macrophage densities and finally upregulation of PD-L1, predominantly expressed on myeloid immune cells (primarily CD68+ macrophages) infiltrating the tumor stroma and to a lesser extent on tumor cells.