The CD4+Foxp3+ cell frequency was also increased after E. rectale (1.0x109 C.F.U/mouse) treatment compared to untreated BD mice (2.07 ± 1.30% vs. 0.75 ± 0.46), (Figure 6N), but the frequencies of CD25+Foxp3+ cells in E. rectale-treated BD mice were not significant among the groups (Figure 6O). The gene discussed is FOXP3; the disease is Behcet disease.