The frequency of CD4+ cells and CD8+ T cells in the PBL of BD mice was lower than in normal mice (11.82 ± 8.54% vs. 34.78 ± 7.25%; 7.42 ± 3.06% vs. 13.10 ± 3.19%, respectively) (Figures 6R, S). This evidence concerns the gene CD4 and Behcet disease.