These include introducing dynamic carrying capacities for tumor and immune cells (101), introducing treatment, IL-2 and IL-12 cytokines (102), incorporating ecological abstraction in APC maturation (27), incorporating NK cells, Tregs and IL-2 cytokines (103), as well as larger scale models that include various stages of activation of effector cells, helper cells, mature Tregs, and various cytokines, such as TGF-beta and IL-10 (26), among others. The gene discussed is IL10; the disease is neoplasm.