In humans, analyses of the TCGA dataset revealed positive mRNA correlations from cutaneous melanoma biopsies for expression of NLRP3 and IL‐6 (p=4.86e-20), IL‐6 and the STAT3 target gene Socs3 (p=1.82e-62), IL-1β and Socs3 (p=1.71e-31) (Supplemental Figures 2B–D). This evidence concerns the gene IL1B and cutaneous melanoma.