In the spleen (Figure 4C), we also observed significant decreased levels of Pdcd1l1 (74%, p<0.01), Arg1 (83%, p<0.01) and Tgfb1 (69%, p<0.05) as well as a non-significant decrease in, Il10. To confirm the role of STAT3 in these NLRP3-mediated changes of PMN-MDSCs, tumor-bearing mice were treated with AZD1480 and PMN-MDSCs were assessed as described above. The gene discussed is STAT3; the disease is neoplasm.