CD8A and neoplasm: In conclusion, based on an in-depth analysis of the multiomic and multidimensional data of KIRP from the largest sample available currently, we found that patients with KIRP whose immune microenvironment exhibits “hot” tumor characteristics are suitable for receiving therapy that causes the reversal of CD8+ T-cell exhaustion, and their C1 and C3 immune subtypes may achieve the best therapeutic effect.