HOXD13 and cancer: Likewise, sPD-1 has also enhanced the anti-cancer immunity induced by CH50 that is a recombinant polypeptide with 2 functional domains (CellI, and HeparinII) for targeting fibronectin which is aberrantly expressed matrix glycoprotein in cancer associated with facilitating tumor growth, invasiveness, metastasis, and resistance to therapy (166, 167).