Significantly higher serum expression of B7-H4 in gastric cancer (242, 243), NSCLC (244, 245), HCC (246, 247), RCC (248–250), bladder urothelial carcinoma (251), ovarian cancer (252, 253), and osteosarcoma (254) has been reported in comparison to normal healthy individuals or control groups. Here, VTCN1 is linked to renal cell carcinoma.