Several solid and hematologic cancers that have shown elevated sPD-1 levels include non-small cell lung carcinoma (NSCLC), HCC, nasopharyngeal carcinoma (NPC), pancreatic adenocarcinoma, advanced rectal cancer, metastatic melanoma, diffuse large B- cell lymphoma (DLBCL), and CLL (124–126, 137, 141–144, 152–156). The gene discussed is HOXD13; the disease is hepatocellular carcinoma.