Compared with AdV-Empty transduced mice, expression of multiple genes were upregulated in lungs of AdV-ACE2 transduced mice infected with SARS-CoV-2, such as several cytokines and chemokines, including TNF, IFN-γ, IL-10, IL-15, IL-6, CCL2, CXCL10, and platelet-derived growth factor subunit B (PDGFb), which was consistent with observations in COVID-19 patients (Table 1; Huang et al., 2020). The gene discussed is IL6; the disease is COVID-19.