Compared with ischemic-type MMD patients, hemorrhagic-type MMD patients had significantly elevated serum level of MMP-9 and MMP-2 (1,186.13 vs. 917.74 ng/ml; P = 0.018 and 326.73 vs. 258.01 ng/ml; P = 0.05, respectively), while no significant differences were observed in the levels of OCLN, CLDN5, VE-cadherin, and JAM-1 between the two groups (Figure 3). This evidence concerns the gene CDH5 and multiminicore myopathy.