MECP2 and systemic lupus erythematosus: Although there are few studies of IRAK1 polymorphisms and the association between IRAK1 gene expression in NMOSD, there were several studies showing that rs3027898 was associated with significant downregulation of IRAK1 mRNA levels (25), and the risk genotype of rs1059702 appeared to act to decrease the mRNA levels of MECP2 (included in IRAK1) in SLE patients (26).