SOX2 and small cell lung carcinoma: For example, approximately 27% of SCLC has a SOX2 amplification (Gadgeel, 2018) SOX2, which encodes a transcriptional regulator of stem cells, promotes initiation and growth of SCLC (Gazdar et al., 2017) SOX2, located on chromosome 3q26.3-q27 is implicated in SCLC by a multiplication of the 3pq26.3 gene locus (Kaufhold et al., 2016).