Similar to the differential microbiota results, systemic inflammatory cytokines were positively correlated with the colon cancer process, and key protein levels of LPS, IL-6, IL-22 and IL-17A in mouse serum were significantly higher after modelling than in the sham group (p < 0.01 or p < 0.01, Figure 6C). Here, IL6 is linked to malignant colon neoplasm.