NFKB1 and malignant colon neoplasm: Dysbiosis of the intestinal flora can lead to alterations in key proteases and metabolites that induce the degradation of E-calmodulin, leading to dysfunction of barrier permeability and activation of Wnt/β-catenin and NF-κB signalling pathways that promote colon cancer development (Elinav et al., 2013).