In this study, CYP3A5 genotype was not significantly associated with schistosomiasis treatment efficacy, although children carrying CYP3A5 defective alleles (*3, *6, *7) were more cured than those with wild type genotype (CYP3A5 *1/*1) (Tables 4 and 5). This evidence concerns the gene CYP3A5 and schistosomiasis.