David et al., 2021 in their MedRixv preprint showed that a common variant of TMPRSS2 protects against COVID-19. In silico screening of several phytochemicals identified that Withanone, one of the constituents of ashwagandha, showed a potential inhibition of ACE2 (Balkrishna et al., 2021). Additionally, Ghosh et al. (2021) used molecular dynamic simulations and pharmacophore modeling approaches to predict the highly potent small-molecule derivative of withaferin A that potentially inhibits SARS-CoV-2 protease (Mpro), a favorable future therapeutic against COVID-19. Here, TMPRSS2 is linked to COVID-19.