LRRK2 and Parkinson disease: Furthermore, some of these pathological trends were exhibited in induced pluripotent stem cells (iPSC)-derived astrocytes from PD patients with a G2019S mutation in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, which is the most common cause of familial PD (Ramos-Gonzalez et al., 2021).