In the context of Alzheimer’s disease (AD), microglial activation has been shown to precede amyloid-β (Aβ) plaque deposition and the formation of tau tangles and may result in enhanced pathology (Yoshiyama et al., 2007; Heneka et al., 2013; Wright et al., 2013; Leyns et al., 2017; Venegas et al., 2017; Ising et al., 2019; Shippy et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.