Similarly, the colonization of a curli-producing gut bacteria, Escherichia coli (E. Coli), in mice overexpressing α-synuclein, a hallmark of synucleinopathies such as PD, was demonstrated to exacerbate disease progression (Chen et al., 2016; Sampson et al., 2020). The gene discussed is SNCA; the disease is Parkinson disease.