APP and Alzheimer disease: These findings are congruent with previous studies that administered an antibiotic cocktail to transgenic APP/PS1 AD mice and showed a reduction in Aβ plaque pathology and plaque-associated microgliosis as well as increased cytokine and chemokine circulation (Minter et al., 2016, 2017; Harach et al., 2017; Dodiya et al., 2019).