Microglia can also activate the NOD, leucine-rich repeat (LRR), and pyrin-domain containing 3 (Nlrp3) inflammasome, which results in the production of Asc specs that cross-seed Aβ plaques and enhance both amyloid and tau-associated pathology in AD (Heneka et al., 2013; Venegas et al., 2017; Ising et al., 2019). Here, MAPT is linked to Alzheimer disease.