NLRP3 and Alzheimer disease: Inhibition of the Nlrp3 inflammasome in AD mouse models was recently shown to reduce Asc speck formation, plaque pathology, and microgliosis, suggesting that Nlrp3 inflammasome activation in microglia could be driving its neurotoxic effects (Lonnemann et al., 2020; Shippy et al., 2020).