For example, in human patients with mild cognitive impairment and AD mouse models, microglia can release pro-inflammatory cytokines that induce neuroinflammation, which can exacerbate AD pathology resulting in increased Aβ plaque deposition, neuronal tau accumulation, and synapse loss (Tarkowski, 2003; Yoshiyama et al., 2007; Wright et al., 2013). Here, MAPT is linked to Alzheimer disease.