The physiological implications include energy production (Lindsay, 1975; Jumpertz et al., 2012; Nakamura et al., 2014; Alcock and Lin, 2015; Cucchi et al., 2019), the trigger of the inflammatory response through via TLR4 signaling pathway associated with pain pathogenesis (Zhang and Ma, 2017), worsening pain (Sekar et al., 2020), and a link to insulin resistance that is proposed to be a part of migraine pathophysiology (Rao and Pearce, 1971; Perciaccante and Perciaccante, 2008; Bhoi et al., 2012; Ozcan and Ozmen, 2019). This evidence concerns the gene INS and migraine disorder.