INS and migraine disorder: Unesterified fatty acids are used for energy, and their levels increase in response to catecholamines, glucagon, or corticosteroids (Zhang and Ma, 2017). Dietary SAFAs worsen pain (Sekar et al., 2020). Higher unesterified plasma fatty acids may also link with insulin resistance proposed to be a part of migraine pathophysiology (Rao and Pearce, 1971; Perciaccante and Perciaccante, 2008). Both CNS and peripheral nervous system myelination depend on de novo fatty acid synthesis.