With that said, many studies point to HDAC6 as a major player in mechanisms that underlie peripheral neuropathy development (d’Ydewalle et al., 2012; Benoy et al., 2017; Krukowski et al., 2017; Ma et al., 2018b; Prior et al., 2018; Sakloth et al., 2020). This evidence concerns the gene HDAC6 and peripheral neuropathy.