MAPT and early-onset autosomal dominant Alzheimer disease: Alzheimer’s disease (AD) is characterized by the deposition of the toxic beta-amyloid (Aβ) protein in the extracellular matrix between neurons, and the formation of neurofibrillary tangle due to the abnormal phosphorylation of tau protein, which could further induce neuroinflammation, oxidative stress, neurodegeneration and even neuronal apoptosis (Yin et al., 2020).