Interestingly, in the experimental autoimmune encephalomyelitis (EAE) model IL-33 can attenuate expansion of Th17 cells through mast cell-mediated alternative activation of macrophages (M2 skew), suggesting mast cells could play an important intermediary role in mediating protective effects of IL-33 [72]. This evidence concerns the gene IL33 and experimental autoimmune encephalomyelitis.