HEPACAM and megalencephalic leukoencephalopathy with subcortical cysts: In particular, the astrocytic plasma membrane signalling cluster incorporates GlialCAM, the regulatory integral membrane protein MLC1 (megalencephalic leukoencephalopathy with subcortical cysts 1), ClC-2 chloride and TRPV4 (cation) channels, receptors (EGF) and transporters (Na+/K+-ATPase)10–14.