In the present study, we designed a customized panel to analyse the tears from chronic SJS patients for the expression of pro-inflammatory cytokines IL-1β, IL-2, IL-6, CXCL8/IL-8, IL-15,IL-17A, bFGF, RANTES, MCP-1, GM-CSF, TNF-α, IFN-γ and anti-inflammatory cytokines IL-10, IL-13 along with ELR-negative CXC chemokines CXCL9 and CXCL10. This evidence concerns the gene IL1B and Schwartz-Jampel syndrome.