Our aim in the present study was to investigate the neuroprotective effects of DHF in the hippocampus and cortex of the brains of Tg26 mice, a murine model for HAND, with a focus on of HIV-1 chemokine coreceptors C-X-C chemokine receptor type 4 (CXCR4)/C–C chemokine receptor type 5 (CCR5) expression, inflammatory activity, mitochondrial damage, and associated signaling mechanisms. This evidence concerns the gene CXCR4 and HIV-associated neurocognitive disorder.