Moreover, we found that inhibition of miR-139-5p under the downregulation of lncRNA NEAT1 exacerbated liver fibrosis in vivo, which was validated by the mRNA levels of miR-139-5p (Fig. S1A), Masson staining and Sirius red staining (Fig. S1B, C), α-SMA immunohistochemical staining (Fig. S1D, E) in liver tissues from Ad-shNEAT1 transfected fibrotic mice treated with miR-SCR or miR-139-5p inhibitor. Here, ACTA1 is linked to Hepatic fibrosis.