AGT and hypertensive disorder: As a matter of fact, hypertension has been identified as one of the major risk factors associating with the severity and fatality of SARS-CoV-2 infection.27,55,56 The hypertension patients normally would have higher levels of angiotensin II, which is the natural substrate for ACE2.57,58 During catalysis, angiotensin II could bind to ACE2, transiently trapping the receptor in the closed conformation.