The results of the present study concludes that the G allele of CASP9 -1263A>G polymorphism might confer risk for the development and progression of CML while CASP9 -712C>T and CASP9 -293 del SNPs might confer protection against development of CML. Here, CASP9 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.