Haplotype analysis performed to find out the association of CASP9 -1263 A>G, CASP9 -712 C>T, CASP9 -293 del and CASP9 Ex5 +32G>A with the development of CML had confirmed that the presence of variant G allele of CASP9 -1263 A>G might be independently conferring risk for the development of CML. Here, CASP9 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.