The haplotype analysis of all four CASP9 SNPs including 3 promoter SNPs and one exonic SNP (CASP9 -1263 A>G, CASP9 -712 C>T, CASP9 -293 del and CASP9 Ex5 +32G>A) was carried out to find out the risk haplotypes for CML development. The gene discussed is CASP9; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.