Furthermore, we compared the overall survival (OS) and disease-free survival (DFS) between patients with IL-8+ and IL-8−, and Bcl3+ and Bcl3−, and IL-8+ Bcl3+ and IL-8−Bcl3− HCC cells on the basis of the Kaplan–Meier method and log-rank test, in which patients with IL-8+, Bcl3+, and IL-8+ Bcl3+ cells exhibited shorter OS times and earlier recurrence (Fig. 5d–f). The gene discussed is CXCL8; the disease is hepatocellular carcinoma.