In contrast, the median number of malignant plasma cells in MM patient samples was decreased in a dose-dependent manner with 50% and 63% of reduction with 2.5 μM and 5 μM of UNC-0379 respectively (p = 0.001 and p < 0.0001; N = 8), whereas non-tumoral CD138-negative BM cells displayed less sensitivity, like normal plasma cells (Fig. 2d). This evidence concerns the gene SDC1 and Miyoshi myopathy.