LRRK2 kinase inhibition reversed pRab10 increases in mutant brain and cultures, but did not reduce postsynaptic AMPAR expression in heterozygous cells (that are most relevant to human PD), or mutant Pr; however, LRRK2 inhibition increased forward traffic of GluA1 to silent synapses in WT. Here, GRIA1 is linked to Parkinson disease.