While our results do not definitively exclude a role for TLR7 in ganglia during infection, since functional changes in the TLR7 receptor, its downstream signaling mediators, or chaperone proteins involved in TLR7 trafficking in lysosomes may occur independent of RNA expression, it is notable that TLR7 in the spleen was significantly upregulated by influenza A suggesting that alterations in TLR7 transcription would be observed in ganglia if TLR7’s role in antiviral defense was similar in both tissues. Here, TLR7 is linked to infection.