TLR7 has recently been shown to serve as a receptor for the endogenous microRNA Let-7b, which may help regulate microglial pruning of neurons in the central nervous system during early development in humans [47] and is elevated in neurodegenerative diseases such as Alzheimer’s [48] where it may contribute to neuronal loss [11, 12]. Here, TLR7 is linked to neurodegenerative disease.