In an in vitro model of cerebral ischemia, Maier et al. found that in neurons, ER stress-mediated binding of the transcription factor C/EBP homologous protein (CHOP) prevented heterodimerization of gamma-aminobutyric acid B receptors (GABABR) and their subsequent trafficking to the cell surface, which diminished GABAB signaling and thus neuronal inhibition [17]. Here, DDIT3 is linked to brain ischemia.