Additionally, YAP1 was identified as the target gene of exosomal miR-550a-3-5p, and miR-550a-3-5p may regulate the growth and migration of HBMECs by mediating YAP1, cleaved-PARP, pRB, CDK6, CTGF, and CYR61 protein expression, thus controlling brain metastasis of lung cancer. The gene discussed is CCN2; the disease is lung cancer.