No differences in PSA concentrations (7.56 ng/mL vs. 6.76 ng/mL), prostate volume (36.55 mL vs. 36.79 mL), or prostate cancer detection rate (62.9 % vs. 62.1 %) were observed between the base-only PNB group and the base and apex PNB group. The gene discussed is KLK3; the disease is Familial prostate cancer.