By binding cereblon (CRBN), thalidomide can activate the E3 ubiquitin ligase CRL4CRBN-mediated ubiquitination and degradation of the IKAROS family transcription factors IKZF1 and IKZF3 [19], which play key roles in the tumorigenesis and progression of hematologic malignancies [20]. The gene discussed is CRBN; the disease is hematologic disorder.