ERBB2 and non-small cell lung carcinoma: During the past few years, various HER2-targeting therapeutic strategies for HER2-mutant NSCLC were developed, including pan-HER inhibitors (afatinib, neratinib, and dacomitinib) [8–10], anti-HER2 antibody drug conjugates (ADCs; such as trastuzumab emtansine [T-DM1]) [11], and emerging irreversible tyrosine kinase inhibitors (TKIs; such as poziotinib) [12].