TLR4 and coronary artery disorder: It has been found that miR-146a/b could be involved in CAD by regulating the TLR4 downstream molecules IRAK1 (interleukin-1-receptor-associated kinase 1) and TRAF6 (tumour-necrosis-factor-receptor-associated factor 6) and its level was significantly higher in the CAD group than in the non-CAD group (all P < 0.01) [20].