HDAC6 and neurodegenerative disease: Pandy et al. used a Drosophila neurodegenerative disease model to research the relationship between autophagy and HDAC6 and found that HDAC6 autophagy is dependent on the inhibition of the ubiquitin–proteasome pathway, which further reveals the complementary relationship between these two degradation pathways (Zheng and Wang 2010; Pandey et al. 2007).