GRM2 and Alzheimer disease: Furthermore, evidence indicates that at least three members of the mGluR family, mGluR2/3 and 5, exhibit sex-biased signaling in neurons [30, 34] and, therefore, it is imperative that we explore whether this sex-selective mGluR signaling is also evident in neuroglia and whether it translates into differences in the pathophysiology of AD between both sexes.