The NLRP3 inflammasome can be activated by high androgen levels, leading to ovarian interstitial cell fibrosis;7 NLRP3 inflammasome activation is associated with the development of renal fibrosis in diabetic nephropathy;8 and NLRP3/IL-1β activation is associated with the formation of cardiac fibrosis.29 However, the relationship between the NLRP3 inflammasome and liver fibrosis has rarely been reported. This evidence concerns the gene IL1B and Hepatic fibrosis.