NLRP3 is an intracellular multiprotein complex that is widely involved in cellular immunity and can respond to harmful signals (pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), thereby activating caspase1 through autocatalysis, releasing proinflammatory cytokines (such as IL-1β and IL-18), and initiating the repair response.5,6 Previous studies showed that NLRP3 inflammasome activation is associated with ovarian,7 kidney8 and heart9 fibrosis. Here, NLRP3 is linked to fibrosis.