NOX4 and Hepatic fibrosis: However, a study of chronic granulomatosis showed that NLRP3 inflammasome activation does not depend on the ROS produced by NOX.33 Perhaps there are other signaling molecules that play indirect roles between NOX4 and NLRP3; thus, clarifying the relationship between NOX4 and NLRP3 inflammasomes in the development of liver fibrosis is very important for future treatment of liver diseases.