The NLRP3 inflammasome can be activated by high androgen levels, leading to ovarian interstitial cell fibrosis;7 NLRP3 inflammasome activation is associated with the development of renal fibrosis in diabetic nephropathy;8 and NLRP3/IL-1β activation is associated with the formation of cardiac fibrosis.29 However, the relationship between the NLRP3 inflammasome and liver fibrosis has rarely been reported. The gene discussed is IL1B; the disease is diabetic kidney disease.