Stimulation of ACE2/Ang(1–7)/MasR axis by DIZE also ameliorates the behavioral deficits and protects the brain against amyloid pathology, inflammatory overactivation, and oxidative damage in animal models of Alzheimer's disease (Evans et al., 2020; Kamel et al., 2018). Here, MAS1L is linked to early-onset autosomal dominant Alzheimer disease.