SPN and infectious otitis media: We found that in the sOP- subgroup (i.e., AOM-free), Corynebacterium_1 (p = 3.5 x 10−5), Dolosigranulum (p = 0.0047), and Actinomyces (p = 8.2 x 10−4) remained at lower abundance in Spn+ samples relative to Spn- samples, but none of the other genera shown in Fig 3A did, and Bacillus became more abundant (p = 0.022) in Spn+ samples from children of 6-month old (Fig 4A).