TUFM and type 1 diabetes mellitus: Although the 19 candidate T1D risk genes in the 16p11.2 locus are expressed at low levels in the pancreas (Fig 3B), the 4 high-probability causal enhancer SNP eQTLs (rs4788084, rs62031562, rs743590, and rs762633) are correlated with increased expression of three genes, SULT1A2, TUFM, and CDC37P1, in 34 tissues, 19 tissues, and 19 tissues, respectively, including the pancreas (Fig 3C).