IL27 and type 1 diabetes mellitus: Taken all together, a model emerges whereby these candidate causal enhancer T1D genetic variants might act to increase the propensity of APCs to present autoantigens and secrete IL27, leading to hyperactivation of T lymphocytes by dysregulation of cAMP-mediated inhibition, a situation which could be further exacerbated by increased expression of TCR signaling genes, thus triggering the onset of T1D.