A study investigating the basis for cardiac hypertrophy reported that Gq protein-coupled receptor agonists induce protein synthesis in cardiomyocytes by stimulating the phosphorylation of S6K1 and eIF4E-binding protein-1 (4E-BP1) via Ras-ERK signaling rather than through AKT and this ability is effectively blocked either by inhibition of MEK or mTORC1 [91]. The gene discussed is RPS6KB1; the disease is cardiac hypertrophy.