TP53 and neoplasm: In addition, a germline TP53 founder PV, c.1010G>A (p.Arg337His), widely referred as R337H, has been reported in Southern Brazil at a frequency of 1 in approximately 300 newborns [7–9], but tumor penetrance appears to be lower than that observed in carriers of DNA-binding domain (DBD) PV [10–13].