Approximately 70% to 80% of patients who fulfill classical criteria will have a germline PV in TP53 [16, 19] When a broader LFS tumor spectrum was considered, a number of different sets of criteria started to be used to identify LFS patients, including the Chompret criteria and other criteria for Li-Fraumeni Like Syndrome (LFL) [19–21]. Here, TP53 is linked to neoplasm.