RNF213 and multiminicore myopathy: In other diseases than MMD, RNF213 variants also lead to a more severe clinical course, e.g., R4810K carrier status was independently associated with recurrent cerebrovascular events in patients with intracranial atherosclerosis [151] and the p.R4810K variant was associated with poor clinical outcomes in patients suffering idiopathic pulmonary arterial hypertension [152].