RNF213 and coronary atherosclerosis measurement: Morimoto et al. published results of bilateral common carotid artery stenosis surgery in RNF213-/- mice and vascular endothelial cell-specific RNF213 mutant (human p.R4810K orthologue) transgenic (EC-Tg) mice, revealing a significantly stronger reduction of CBF in the RNF213-/- mice than in wild-type mice [156].