Liao et al. conducted a meta-analysis, again confirming association of RNF213 p.R4810K, which significantly increased familial MMD risk in the Japanese, Korean and Chinese population (dominant model ORs 1802.44, 512.42, and 1109.02), with 5–36 times larger effect sizes than that for sporadic cases (dominant model ORs 134.35, 99.82, and 30.52). This evidence concerns the gene RNF213 and multiminicore myopathy.