Whereas significantly reduced CD63 expression in response to TRAP stimulation at all time points was found compared to healthy controls (e.g., CD63 expression in percentage day 1 vs. healthy: 48.9 ± 3.1 vs. 73.5 ± 4.6, p < 0.001), platelet CD63 expression in ECMO patients in response to TRAP was not different from CAD patients. This evidence concerns the gene CD63 and coronary artery disorder.