CD4 and colorectal carcinoma: Although statistical significance was not reached due to low statistical power, intermediate-onset CRC tended to show lower densities of overall macrophages (median [interquartile range, IQR], 357 [152–670]), M1-like macrophages (45 [18–114]), CD14+HLA-DR+ cells (mature macrophages) (479 [233–967]), and CD3+CD4+FOXP3+ cells (regulatory T cells) (0 [0–2.0]) compared to later-onset CRC (453 [254–811], P = 0.050; 91 [31–211], P = 0.062; 730 [377–1239], P = 0.015; 0.9 [0–8.5], P = 0.039, respectively).